Seminars in Dialysis this month have published an excellent review of the diagnosis and treatment of peripheral vascular disease in patients with CKD. This is something that we deal with on a regular basis in the clinic and…
AJKD this month has an extended editorial section on the KDOQI guidelines for CKD. It is now 10 years since these guidelines were introduced and their impact on nephrology has been significant, not least due to the fact…
Despite the fact that the kidney ultrasound is generally obtained as one of multiple recommendations when evaluating AKI, the benefit of kidney ultrasound is not clear. The post-renal causes of AKI are not very common. It adds to…
The topic of IgA nephropathy has been discussed in multiple posts here in the past. IgA is the commonest primary GN with a wide variety of presentations and prognoses ranging from isolated hematuria to a rapidly progressive GN….
A couple of years ago, it was noted that mTOR inhibitors slowed the growth of cysts in animal models of Polycystic Kidney Disease. Although the activity of mTOR is minimal in normal renal epithelial cells, in cyst epithelial…
Last year, we had a post about Bardoxolone for the treatment of diabetic nephropathy. After one year of treatment, eGFR increased significantly in patients treated with Bardoxolone relative to controls. At the time, significant concerns were raised about…
At some point during evolution humans lost the enzyme uricase and during the long and tedious process of getting to the modern age and this was initially a good thing. Uric acid accumulation as a result of uricase…
This month’s eJournal Club article is not a traditional, clinical or basic research article but instead one which looks into the state of nephrology training in the US. There has been a significant decline in the number of…
When I got my US driving license, I was asked whether or not I would like to be an organ donor. To me, having seen the positive effects of donation on the lives of my patients down through…
In the quest for better solute clearance, two divergent paths were taken on each side of the Atlantic. The US nephrology community has concentrated more on low weight molecules. The European counterpart has focused on both low and…
