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Beyond RNA: How Integration of Single Nucleus Chromatin Accessibility Sequencing Can Help our Understanding of the Kidney
Eryn E. Dixon, PhD Washington University School of Medicine in St. Louis The reach of single cell sequencing technologies continues to rapidly expand across tissue and disease models with the introduction of multi-omic approaches. Here, we continue our…
Why are females better than males? A kidney perspective.
Brandon E. McFarlin, Ph.D. CandidateKeck School of Medicine of University of Southern California Cardiovascular disease (CVD) is the leading cause of death globally – estimated at 17.9 million lives annually. A major risk factor for CVD is hypertension…
Microdialysis: A Method For Studying Kidney Injury and Disease
Casey DerellaPhD Candidate Augusta University Microdialysis is a clinical and laboratory research tool used in a variety of fields from drug development, cancer research, physiology, and even ecology. Microdialysis provides insights to biochemical changes in the tissues before…
Three-dimensional tissue cytometry: Novel strategy to interrogate cell spatial location
Laurence Black, PhDPostdoctoral FellowUniversity of Alabama at Birmingham Precision medicine is an exciting approach to treat diseases on an individual basis that considers and incorporates the genetic make-up, environment, and lifestyle of each patient to develop personalized therapeutic…
Cell by cell: A sequencing specific approach to kidney disease
Eryn Dixon, PhD Washington University School of Medicine in St. Louis Kidney cell type diversity, complexity, and interaction mechanisms are a source of intrigue and frustration for many. With more than 20 different, specialized cell types (Quaggin, 2019),…
Ammonia and bicarbonate: potential mechanisms underlying the benefits of alkali therapy in chronic kidney disease
Clayton BradyMD/PhD Candidate (G2)University at Buffalo Jacobs School of Medicine and Biomedical Sciences Acid-base balance is often overlooked in healthy individuals, but becomes glaringly important in any patient with reduced kidney function. Our kidneys do a tremendous job…
Evolving function of the gut microbiota in kidney disease
Justine Abais-Battad, PhDInstructor, Medical College of Georgia at Augusta University Over the last decade we have witnessed surging scientific and public interest in the gut microbiota and its relationship to our overall health. German philosopher Ludwig Feuerbach said…
Influence of Circadian Clock on Blood Pressure Control
Ryan Crislip, PhDPostdoctoral FellowUniversity of Florida The circadian field has gained recent notoriety from three distinguished scientists (Jeffrey Hall, Michael Rosbasch, and Michael Young) being awarded the Nobel Prize in Physiology or Medicine in 2017 for their isolation…
Dietary Habits as a Potential Therapeutic Approach for Chronic Kidney Disease
John Henry Dasinger, PhDPostdoctoral FellowAugusta University George Bernard Shaw, Irish playwright and Nobel Prize winner, said it best, “There is no love sincerer than the love of food“ George Bernard Shaw In the current coronavirus infectious disease 2019…
Evolutionary role for aldosterone in females: implications for hypertension therapy
Jessica Faulkner, PhDPostdoctoral FellowAugusta University Aldosterone production and mineralocorticoid receptor (MR) activation is a key physiological pathway promoting retention of salt and water in the distal nephron. Aldosterone is a physiological ligand of MR and MR activation leads…