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Influence of Circadian Clock on Blood Pressure Control
The circadian field has gained recent notoriety from three distinguished scientists (Jeffrey Hall, Michael Rosbasch, and Michael Young) being awarded the Nobel Prize in Physiology or Medicine in 2017 for their isolation and characterization of the circadian gene…
Dietary Habits as a Potential Therapeutic Approach for Chronic Kidney Disease
George Bernard Shaw, Irish playwright and Nobel Prize winner, said it best, “There is no love sincerer than the love of food“ George Bernard Shaw In the current coronavirus infectious disease 2019 (COVID-19) pandemic, many of us may…
Evolutionary role for aldosterone in females: implications for hypertension therapy
Aldosterone production and mineralocorticoid receptor (MR) activation is a key physiological pathway promoting retention of salt and water in the distal nephron. Aldosterone is a physiological ligand of MR and MR activation leads to increased epithelial sodium channel…
Better Together: Novel Model Sets the Stage for Understanding Urate Excretion by Intestines and Kidneys
Uric acid is the final metabolic byproduct of purine nucleotide breakdown (Figure 1a) and its accumulation causes hyperuricemia, which is highly prevalent and heritable. The major consequence of this pathological elevation of serum urate, which affects 43 million…
Physical Activity in Patients with Chronic Kidney Disease: Lessons From Basic Science
Exercise and physical activity of any kind provide a substantial number of health benefits. In fact, the 2018 Physical Activity Guidelines from the American College of Sports Medicine (ACSM) recommend that some exercise is better than none. However,…
Are the Kidneys at Risk in Patients with Cystic Fibrosis?
Music City USA is home to The Grand Ole Opry, The Music Hall of Fame and from October 31st to November 2nd, was home to the 2019 North American Cystic Fibrosis Conference (NACFC). More than 5,000 researchers and…
What do we (NO) about tubuloglomerular feedback?
The kidney is all about balance; specifically the balance of fluid and electrolytes. This is in the face of sometimes an incredible onslaught of perturbations in homeostasis. To accomplish this impressive feat, the kidney is equipped with a…
Anti-Inflammatory Benefits of Metabolic Acidosis Treatment in CKD
As an avid spicy-food eater, I quickly learned the many home-remedies to help with the dreaded heartburn that often accompanies my jalapenos and hot wings. My secret? Well, without fail, a spoonful of Arm & Hammer baking soda…
Organ-On-A-Chip: Novel Direction of Physiology Research and Drug Development
Scientific technology is advancing quicker than ever before. Something I never thought I would be saying in my lifetime is that science now has the technology to create an Organ-On-A-Chip. An Organ-On-A-Chips is an engineered in vitro modelled…
Practice to Bench: The Reverse Engineered Pathway For Discovering Nephrotoxicity
Drug related adverse events may not be uncovered until new therapies have been on the market for many years and used among a wider patient population than in the initial clinical trials. Downing and colleagues summarized that, during…