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Cell by cell: A sequencing specific approach to kidney disease
Eryn Dixon, PhD Washington University School of Medicine in St. Louis Kidney cell type diversity, complexity, and interaction mechanisms are a source of intrigue and frustration for many. With more than 20 different, specialized cell types (Quaggin, 2019),…
Ammonia and bicarbonate: potential mechanisms underlying the benefits of alkali therapy in chronic kidney disease
Clayton BradyMD/PhD Candidate (G2)University at Buffalo Jacobs School of Medicine and Biomedical Sciences Acid-base balance is often overlooked in healthy individuals, but becomes glaringly important in any patient with reduced kidney function. Our kidneys do a tremendous job…
Evolving function of the gut microbiota in kidney disease
Justine Abais-Battad, PhDInstructor, Medical College of Georgia at Augusta University Over the last decade we have witnessed surging scientific and public interest in the gut microbiota and its relationship to our overall health. German philosopher Ludwig Feuerbach said…
Influence of Circadian Clock on Blood Pressure Control
Ryan Crislip, PhDPostdoctoral FellowUniversity of Florida The circadian field has gained recent notoriety from three distinguished scientists (Jeffrey Hall, Michael Rosbasch, and Michael Young) being awarded the Nobel Prize in Physiology or Medicine in 2017 for their isolation…
Dietary Habits as a Potential Therapeutic Approach for Chronic Kidney Disease
John Henry Dasinger, PhDPostdoctoral FellowAugusta University George Bernard Shaw, Irish playwright and Nobel Prize winner, said it best, “There is no love sincerer than the love of food“ George Bernard Shaw In the current coronavirus infectious disease 2019…
Evolutionary role for aldosterone in females: implications for hypertension therapy
Jessica Faulkner, PhDPostdoctoral FellowAugusta University Aldosterone production and mineralocorticoid receptor (MR) activation is a key physiological pathway promoting retention of salt and water in the distal nephron. Aldosterone is a physiological ligand of MR and MR activation leads…
Better Together: Novel Model Sets the Stage for Understanding Urate Excretion by Intestines and Kidneys
Eryn DixonPostdoctoral FellowWashington University School of Medicine in St. Louis Uric acid is the final metabolic byproduct of purine nucleotide breakdown (Figure 1a) and its accumulation causes hyperuricemia, which is highly prevalent and heritable. The major consequence of…
Physical Activity in Patients with Chronic Kidney Disease: Lessons From Basic Science
Casey DerellaPhD CandidateAugusta University Exercise and physical activity of any kind provide a substantial number of health benefits. In fact, the 2018 Physical Activity Guidelines from the American College of Sports Medicine (ACSM) recommend that some exercise is…
Are the Kidneys at Risk in Patients with Cystic Fibrosis?
Music City USA is home to The Grand Ole Opry, The Music Hall of Fame and from October 31st to November 2nd, was home to the 2019 North American Cystic Fibrosis Conference (NACFC). More than 5,000 researchers and…
What do we (NO) about tubuloglomerular feedback?
The kidney is all about balance; specifically the balance of fluid and electrolytes. This is in the face of sometimes an incredible onslaught of perturbations in homeostasis. To accomplish this impressive feat, the kidney is equipped with a…