In a year which gave us the bardoxolone failure, NEPHRON-D and the CORAL trial to name a few, a study with a positive result should be celebrated and the RAVE follow-up must be a contender for top 10…
The JC virus is a member of the Polyomavirus family, which includes the BK virus. It infects about 80% of healthy adults and establishes latency in renal tissue. It was first isolated in 1971 from the brain of…
At ASN Kidney Week there was some interest in abatacept as a targeted therapy for glomerular diseases. T-cell activation requires 2 signals; (i) binding of the T-cell receptor to the antigen-MHC complex on the antigen-presenting cell and (ii)…
There have been a number of studies reported in the past month which broaden our understanding of the complexity of alloantibodies post kidney transplant. It is well recognized that the presence of donor specific anti-HLA antibodies (DSA) infers a…
A 54 year old man was referred to the Nephrology service due to AKI after presenting with lethargy and severe thirst. He had a long history of pulmonary and hepatic sarcoidosis which had been quiescent for some time….
There has been lots of new data in the AAV literature of late. We have new nomenclature, including the dropping of Freidrich Wegeners name for the more generic but descriptive granulomatosis plus angiitis (GPA), by the Chapel Hill…
The post from Veeraish earlier this week reminded me of this patient who demonstrated an important learning point regarding hypokalemia in hypothermic patients. A 75 year old woman was found unconscious in her unheated home with overnight temperatures…
There has been much recent interest in novel extra-corporeal treatments for removal of nephrotoxic free light chains (FLC) in myeloma cast nephropathy. HCO dialyzers employ high flux membranes with particularly large pores (up to 50kDa Vs 15kDa for…
