I was not surprised to learn that there have been a number of studies that have attempted to identify the optimal time of RRT initiation in AKI. While early case-control and retrospective studies suggested “early” RRT reduced mortality, two randomized clinical trials produced conflicting results. In 2002, a trial of 106 patients initiated “early” RRT if urine output was less than 30ml/hr after six hours but did not find a difference with regard to mortality or recovery of renal function in survivors. A 2004 trial found a large reduction in mortality with early dialysis, defined by postoperative urine output, (RR 0.17 95%CI 0.05-0.61) but weak methods and a small sample size (N =28) temper this conclusion. Observational data from PICARD have shown that the risk of death in critically ill AKI patients was significantly decreased by initiating RRT before levels of blood urea nitrogen were greater than 76mg/dl (adjusted hazard ratio 0.54, CI 0.34 to 0.86).
Such a confusing and contradictory set of conclusions suggests perhaps that neither BUN or creatinine nor urine output is the best guide to the decision to initiate RRT. A number of studies from the pediatric world have emerged over the past 10 years that suggest that the percent fluid overload (%FO) may be key. Specifically, retrospective work from the Prosepective Pediatric Continuous Renal Renal Replacement Therapy (ppCRRT) registry has repeatedly suggested that RRT initiation in AKI when at %FO of around 10% results in decreased mortality, independent of illness severity (see here, here, here and here). Similar findings have more recently been reproduced in adult studies (SOAP, PICARD) where positive fluid balance in AKI was found to correlate with increased mortality.
While some may argue that positive fluid balance merely correlates with illness severity, there seems to be an emerging notion that fluid accumulation in AKI is not an innocuous process but one with significant consequences.
Matt O’Rourke, MD