Eculizumab is a humanized monoclonal antibody (mAb) that binds the complement protein C5 blocking its cleavage into C5a and C5b, thereby preventing the formation of the C5b-9, the Membrane Attack Complex (MAC). Eculizumab is FDA approved for the…
A young patient was recently transferred to our service for evaluation of acute renal failure that had developed many years following a liver transplant for PSC. She had presented to another institution with nausea, vomiting, fevers and a…
The whole fiasco about the antenna and reception issue with the iPhone 4 made me realize that unlike other professions, where several chances exist to rectify a problem, clinicians often have only one chance to get it right…
Hemolytic Uremic Syndrome is characterized by the triad of Microangiopathic hemolytic anemia Thrombocytopenia Renal failure. The disease is broken down into Typical, or diarrhea associated Atypical, or diarrhea negative cases. 90% of HUS cases in the United States…
