Though adult nephrologists infrequently encounter these disorders in clinic, the Board Exam loves them. Below a short table describing some of these gain- and loss-of-function channel disorders that are worth remembering. The diuretic-targeted channels are shown under parenthesis as a reference.
Thx Dr Rondon. There are actually two types of Pseudohypoaldo type1: AD which has a defect on aldosterone receptor and AR that has defect on ENaC.
Great table ! Just an observation: Autosomal Dominant Pseudohypoaldosteronism type 1 actually involves a loss of function mutation of the mineralocorticoid receptor, not of ENaC