Diabetic nephropathy (DN) is a major cause of ESRD worldwide. While many attempts have been made to develop reliable animal models that mimic human disease—ob/ob, db/db obese diabetes type 2 diabetes models, NOD1 mice, streptozotocin (STZ)-induced diabetes model…
Azilsartan medoxomil is a relatively new angiotensin receptor blocker and a study was recently published in Hypertension which compared the combination of two different doses of this drug with chlorthalidone against olmesartan in combination with hydrochlorothiazide for the…
Treating hypertension on pregnancy sometimes feels a little like going back in time. As Nate posted previously, the list of anti-hypertensives that are considered safe in pregnancy is relatively short – first line agents include labetalol, hydralazine, methyldopa…
I’ve always been skeptical about ACE inhibitors as a cause of hyponatremia, despite there being almost 20 case reports of this complication in the literature. Given the fact that so many patients I see are taking an ACE…
In the summer of 2010, I came across a health report on the national news that was titled “Angiotensin Receptor Blockers Linked to Cancer”. The headline was based on a publication that demonstrated an increased cancer signal associated…
I must admit that I have always routinely advised holding ACE/ARB prior to major surgery, given the possibility of hemodynamic instability and assumed risk of AKI due to impaired renal autoregulation when perfusion pressure is low. I’m prepared…
Back to the subject of ACE inhibitors again. There are a number of reasons why ACEi might be particularly beneficial for patients on PD and two recent editorials in KI and CJASN laid these out very well. 1….
As mentioned in a previous post, there is not much salt available in the Amazon and as a result, the inhabitants (human and otherwise) have developed very active renin/angiotensin systems in order to retain whatever salt they can…
Coming to the transplant clinic from 2 years of CKD clinic, prescribing ACEI/ARBs was a habit, a good one I guess. Does this hold truth in the transplant world, well… I am not sure anymore after I read…
Since the retraction of the COOPERATE trial by the Lancet late last year (following Regina Kunz’s famous ‘letter of concern’), combination RAAS blockade has suffered something of a fall from grace. This was dealt a second blow by…
