Creatininase
There was a fascinating case published a couple of months ago in the American Journal of Medicine. I have a particular interest in this case as it was my clinic mentor, Julian Seifter, who made the diagnosis and…
Time for a change?
This month’s issue of NDT has an interesting debate concerning whether or not clinical laboratories should start reporting CKD-EPI GFR instead of MDRD. The pro side is here while the con side is here. Basically, the argument for…
MDRD vs CKD-EPI in Transplantation
With the results of the eAJKD brackets posted by Gearoid, I thought this article might be pertinent to stimulate further the debate… This article just came out on Transplantation and is a well designed study in which the…
A picture is worth…
Often on rounds with medical students or housestaff we will review why a serum creatinine of 0.8 mg/dl in a 40 year old athlete… may mean a much higher creatinine clearance than a creatinine of 0.8 mg/dl in…
Something about this doesn’t seem quite right…
There was an interesting case report in KI earlier this year. It concerned a 69yr old man with a history of benign prostatic hyperplasia and Waldenstrom’s Macroglobulinemia (WM) who was admitted for the workup of renal failure. His…
Nephron number, not glomerular filtration rate
Nephrologists for many years have been able to accurately measure kidney function, a measure termed the glomerular filtration rate or GFR. To this end we have been the envy of many other specialties. However the GFR can be…
Creatinine: A Cautionary Tale
In recent months I’ve been seeing a number of referrals for patients with creatinine values in the normal range but eGFR as reported by the lab at below 60ml/min. This is particularly the case in middle aged women….