Important new findings were recently published in relation to proteinuria and FSGS, which are definitely of interest to our community. First, the punch line: There is new evidence for a “circulating factor” in recurrent FSGS in a fascinating…
Gearoid did a nice job reviewing the recent exciting findings surrounding primary Focal Segment Glomerulosclerosis (FSGS) and I thought it would be a good opportunity to review some of the sometimes confusing terminology and clinical basics. To start,…
As has been mentioned in previous post, the identification of the anti-PLA2R antibody has the potential to revolutionize the diagnosis of membranous GN and is already being used clinically on a small scale. It is found in 70%…
We recently saw a case of adult-onset dense deposit disease (DDD) at pathology conference. DDD is rare, affecting 1-3 per million people. For historical reasons it has been classified under the membranoproliferative subgroup of disease patterns (as type…
Focal segmental glomerulosclerosis (FSGS) is a clinicopathologic syndrome manifesting with proteinuria, usually of nephrotic range. Early in the disease process, there is a pattern of glomerular sclerosis that is focal, involving a subset of glomeruli, and segmental, involving…
A very interesting article in this month’s JASN by Herlitz et al describes a cohort of 10 bodybuilders with chronic kidney disease, making a compelling case that anabolic steroid use is an underrecognized cause of secondary FSGS. The…
The histology of HIVAN (HIV-Associated Nephropathy), at the light microscopy level, is indistinguishable from that of collapsing FSGS: the glomerular capillary loops are collapsed. Furthermore, both entities demonstrate foot process effacement (as in all forms of nephrotic syndrome)…
What’s the most common cause of ESRD in the U.S. after diabetes? The classic answer here is “hypertension”, though this answer is a controversial one, as there are many who believe that hypertension alone is not sufficient to…
Identifying the “permeability factor” for patients with FSGS or minimal change disease has been one of the “holy grails” of nephrology, and our inability to identify such a factor has not been for any lack of trying. One…
