Oxalate is a terminal metabolite in humans. Glyoxylate becomes glycine and pyruvate via alanine-glyoxylate aminotransferase (AGT) action, and excess glyoxylate gets converted to oxalate by lactate dehydrogenase (LDH) and glycolate oxidase. Besides being derived endogenously through metabolism, oxalate…
Patient is a 37-year-old female with cystic fibrosis, recurrent nephrolithiasis who presents to clinic with asymptomatic bilateral kidney stones (8mm on right; 2mm on left) on imaging. What type of stone and why cystic fibrosis (CF) is associated…
Hyperoxaluria is an important risk factor for kidney stones, approximately 80% of which are primarily composed of calcium oxalate. Hyperoxaluria is typically diagnosed by performing a 24 hour urine collection and levels above 45 mg/day are considered abnormal…
I recently saw an interesting case series published in CJASN where they reported four cases of oliguric AKI associated with synthetic cannabinoids use. Renal biopsy revealed acute tubular injury in three of them and calcium oxalate crystals in…
Recently, I evaluated an older gentleman with diabetic nephropathy who had undergone a living related kidney transplant from a family member. He underwent Roux-en-Y bypass with an approximate 80 lbs. weight loss prior to his transplant to achieve…
