Oxalate nephropathy: innocent bystander or primary driver of CKD
Oxalate is a terminal metabolite in humans. Glyoxylate becomes glycine and pyruvate via alanine-glyoxylate aminotransferase (AGT) action, and excess glyoxylate gets converted to oxalate by lactate dehydrogenase (LDH) and glycolate oxidase. Besides being derived endogenously through metabolism, oxalate…