Lithium has been a very efficacious drug in the management of bipolar and other mood disorders. There are several aspects of lithium use that Nephrologists need to be mindful of including its pharmacokinetics, its dosing and target concentrations,…
Renal transplantation reduces mortality in elderly patients by more than 50%, however, challenges are magnified in elderly renal transplant recipients (RTR) when managing their pharmacotherapy regimen. Aging is associated with changes in several pharmacokinetics parameters including absorption, distribution, metabolism,…
Tacrolimus comes in oral, intravenous and topical formulations. Prograf is the most commonly used oral tacrolimus formulation and is dosed twice daily. Prograf pharmacokinetics Absorption: Absorption occurs in the small intestine. Drug levels reach a maximum concentration in…
