
An even more economic treatment logically presents itself: drink more water! It is not known whether or not this would have a long-term benefit, but the recommendation to drink 3L of water a day (a recommendation which is fairly routine for stone-formers) would be predicted to decrease ADH levels by approximately 50%.
PKD patients also should be advised to avoid health products which contain forskolin–a potent stimulator of cAMP, which would therefore be predicted to accelerate cyst growth. Forskolin is an ingredient in various bodybuilding supplements and other non-FDA-regulated health care products.