The Different Colors of Peritoneal Dialysate

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Image generated by Arrsh Bajaj using Microsoft Copilot at https://copilot.microsoft.com/

During a night call in my first year of nephrology fellowship, I was asked a question that I had never heard before: ‘What do we do when we see black effluent draining out of the peritoneal dialysis (PD) catheter?’

With a detailed literature review, investigations and discussion on rounds, we were able to determine that this black color was due to the leakage of india ink into the peritoneum from a colonoscopy earlier in the day.

As we encounter more patients on PD, it is important to review the different colorful aberrations in peritoneal effluent that have been reported in the medical literature so far.

Color Possible Etiologies 
Black or Black-Brown
  • Endoscopic tattoo (India ink)
  • hemorrhage/ evidence of RBCs into the peritoneum (hemorrhagic pancreatitis)
  • Rhabdomyolysis (heme combining with albumin in the peritoneum)
Brown or Greenish-Brown
Fluorescent Yellow
Orange
  • Patient on rifampicin therapy
Purple (not seen anymore)
Peach Color
Milky White (Chyloperitoneum)
  • Lymphatic obstruction (lymphoma, lymphangioleiomyomatosis)
  • Excessive lymph production/decreased drainage (congestive heart failure, constrictive pericarditis, superior vena cava syndrome, cirrhosis)
  • Trauma (blunt or penetrating, abdominal surgery, thoracic duct trauma)
  • Drugs ( dihydropyridine calcium channel blockers like nifedipine and direct renin inhibitor aliskiren)
  • Infections (Tuberculosis, filariasis)
  • Systemic diseases such as pancreatitis, systemic lupus, sarcoidosis, retroperitoneal fibrosis
Red (Hemoperitoneum)
  • Gynecologic (menstruation, ovulation, endometriosis, ovarian tumor, rupture of ovarian cyst)
  • Renal (renal angiomyolipoma, renal cancer, rupture of renal cysts)
  • Catheter associated trauma
  • Coagulopathy or anticoagulation therapy  

Cloudy

  • Peritonitis
  • Serositis

As we can see from the table above, the color of the peritoneal effluent can be a clue to complex pathophysiologies within the human body. It is important to keep these differentials in mind when encountered with such a situation. I wanted to highlight the work of Thomas Dossin and Eric Goffin who provided photographs with a comprehensive review of this topic. Other articles and pictures have been referenced through the hyperlinks provided.

Management depends on the etiology but prompt investigation is warranted. There have been recent updates to the ISPD guidelines which talk about possible strategies to deal with such situations.

Post by: Arrsh Bajaj 

Bluesky: @drcoolbeans.bsky.social

Reviewed by: Samira Farouk, Matthew A. Sparks

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