NephMadness 2014 Part 8 – Biologics Bracket
This is a really exciting bracket and is full of new agents that will hopefully lead to major advances in our field. Acthar is the outlier here as, even though it is a peptide, it is not an…
Antibody-Mediated Rejection: Choose your weapons
Acute humoral or antibody-mediated rejection (AMR) is attributed to the presence of alloantibodies against the graft, which could be either antibodies against human leukocyte antigens (HLAs) Class I and/or II , non-HLA antigens or endothelial antigens. Diagnosis of…
Bortezomib in Myeloma Cast Nephropathy
Bortezomib is a proteosome inhibitor used primarily in the treatment of relapsed myeloma. However, it is increasingly being used in the management of myeloma cast nephropathy (MCN). Bortezomib binds to, and inhibits the function of, the 26S proteosome…