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Mmm, let’s try rituximab

Mixed cryoglobulinemia (MC) is a systemic vasculitis in which B cell clones produce IgM with rheumatoid factor activity. The disease can range in severity from isolated skin lesions to full blown renal and neurological involvement. Most patients are…

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Classification of Cryoglobulins and MPGN

Cryoglobulinemia is characterized by the presence of circulating antibodies which precipitate at cooler temperatures, and not infrequently leads to renal failure/glomerulonephritis. The stereotypical histologic lesion of cryoglobulinemia is membranoproliferative glomerulonephritis, which takes the appearance on light microscopy of…

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Renal Disease in Sjogren’s Syndrome

Sjogren’s syndrome is an autoimmune disorder in which there is immune-mediated damage to the exocrine glands which produce tears and saliva.  Many patients (up to 25%) will have extraglandular manifestations of the disease, one of the possibilities of…

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hepatitis C & cryoglobulinemia

Prior to the discovery of the hepatitis C virus (viral particles shown on the left), there was an entity termed “essential cryoglobulinemia”–that is, cryoglobulinemia without an obvious explanation.  While this term is still used, the true “essential cryoglobulinemia”…

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The Cryocrit

Whenever you recommend that “cryoglobulins” be drawn on a patient, it is important to realize that the specimen must be collected in a very specific way. It cannot be simply “added on” to a specimen already drawn. Cryoglobulins…

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