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Naoka Murakami

Keep cool and carry on…

Delayed graft function (DGF) after kidney transplant is associated with long-term allograft dysfunction. Niemann et al. (NEJM 2015;373:405) reported that therapeutic hypothermia reduced DGF (defined here as the requirement of dialysis in the recipient within 7 days after…

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mTOR Pathway in Anti-phospholipid Syndrome

Antiphospholipid syndrome (APS) is an autoimmune hypercoagulable disorder characterized by small-to-large vascular (both arterial and venous) thrombosis with end-organ damages, in presence of circulating antibodies against phospholipid binding proteins. Kidney transplantation in patients with APS is challenging because…

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Lessons from the Akita mouse

Diabetic nephropathy (DN) is a major cause of ESRD worldwide. While many attempts have been made to develop reliable animal models that mimic human disease—ob/ob, db/db obese diabetes type 2 diabetes models, NOD1 mice, streptozotocin (STZ)-induced diabetes model…

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