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Nathan Hellman

Immunosuppressant Drugs in Pregnancy

Is something missing in your life?  Is it the opportunity to take multiple-choice exams?  If so, check out this 10-question ASN-sponsored practice test designed to prepare Nephrology Fellows to be ready for the upcoming Nephrology Boards in November….

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Stone Disease in ADPKD

Patients with ADPKD are predisposed to nephrolithiasis. The postulated reasons for this increased prevalence of stone disease have ranged from metabolic abnormalities (previous reports have shown an increased tendency for hyperoxaluria, hypercalciuria, hypocitraturia, hyperuricosuria, and distal RTA) to…

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Congenital analbuminemia

Plasma oncotic pressure is important to prevent edema, right? And you would think that albumin, which plays a critical role in the binding of multiple plasma proteins and ionized calcium, is essential to life, right? The rare, autosomal…

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EMT = epithelial-to-mesenchymal transition

The three letter acronym EMT:  what should it mean to nephrologists?  Not just “emergency medical technician”…but also “epithelial-to-mesenchymal transition.”   As we all know the nephron is comprised of a long tube of highly-differentiated epithelial cells.  These cells…

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The Important Stuff

It’s important to teach your kids the important stuff in life…like, for instance, the fact that the kidneys are located in a retroperitoneal location, as demonstrated by my daughter.

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atheroembolic renal disease

I heard a lecture not too long ago on atheroembolic renal disease which claimed that atheroembolic renal disease is to nephrology as sarcoidosis is to internal medicine. That is to say, it can present in a myriad of…

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Reticular Inclusions in HIVAN

The histology of HIVAN (HIV-Associated Nephropathy), at the light microscopy level, is indistinguishable from that of collapsing FSGS: the glomerular capillary loops are collapsed. Furthermore, both entities demonstrate foot process effacement (as in all forms of nephrotic syndrome)…

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MMF Basics

Mycophenolic acid is a commonly encountered medication in nephrology. In addition to its use in the vast majority of kidney transplant recipients as part of the immunosuppressive regimen, it is also gaining popularity in the treatment of immune-mediated…

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Rituxan for Membranous Nephropathy?

Clinical trials evaluating the efficacy of various therapies of membranous nephropathy is a tricky business, given the natural history of the disease: because about 1/3 of patients spontaneously remit, it is often difficult to say that a patient’s…

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