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Conall O’ Seaghdha

The Nephrologist as Team Leader

Within the last 2 years dialysis facilities in the US have been adjusting to the now not-so-new Center for Medicare & Medicaid Services (CMS) Conditions of Coverage. CMS, as many of you know, funds the ESRD program to…

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Mythbusters: Hypertension

It seems like there have been a lot of recent developments in the management of hypertension, and several sacred cows have become burgermeat. I thought I’d summarize a few of these important developments here: 1. Blood pressure targets…

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Creatinine: A Cautionary Tale

In recent months I’ve been seeing a number of referrals for patients with creatinine values in the normal range but eGFR as reported by the lab at below 60ml/min. This is particularly the case in middle aged women….

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A Man’s Best Friend

I’m sure many of you have a pet dog. Well, as Rover quietly licks himself in the corner, few would believe that he may hold the key to unlocking the genetic secrets of human disease, as suggested by…

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Tamm-Horsfall Protein and Kidney Disease

Tamm-Horsfall protein (THP), or uromodulin, is a glycoprotein secreted by the renal epithelium, best known as the proteinacious framework of all urinary casts. It’s function in health is an enigma, but prevention of bacterial colonization of the urinary…

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Warfarin and Vascular Calcification

Warfarin has recently been associated with an increased risk of stroke in ESRD patients with atrial fibrillation. This makes the decision whether to initiate warfarin therapy in dialysis patients with atrial fibrilltion anything but clear cut. Add to…

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The trials of a lab rat…

I was on the phone to one of my friends the other day. He’s a renal fellow currently doing lab-based research in Boston. He’s been having a difficult time of it lately, with none of his experiments working…

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