That’s right you read the title correctly- it reads orthostatic hypertension and not hypotension. Ordering orthostatics on patients is quite common. Most of the time the clinical query is in regards to the latter (hypotension). My mentor,…
I’ve recently had a few calls from our outpatient dialysis unit about patient’s with rises in their blood pressure during and after dialysis. Intradialytic hypotension is a very common phenomenon and it’s been interesting to learn that intradialytic…
Average fructose intake in the U.S. is staggering: Americans currently consume approx. 150 pounds of sugar a year, which is 20 times the amount their European ancestors would have ingested from fruit (Data from USDA). This intake is…
Researchers from the UK published a new and exciting article exploring one of the fundamental mechanisms of blood pressure regulation by the renin-angiotensin-system (RAS). This research was, per the authors, 20 years in the making and was fittingly…
Hypertension continues to be major public health concern. Efforts to manage this sometimes difficult to treat condition have only started to positively impact patient health. In some instances hypertension can be refractory to intense medical therapy. It is…
Lisa Cohen recently summarized rare “genetic” forms of hypertension including Liddle’s syndrome and PHA type II (Gordon’s syndrome). I want to summarize other causes of “secondary” hypertension which are not inherited (at least not typically in a Mendelian…
And now for some board review tidbits! Below are some genetic causes of hypertension attributable to specific gene mutations. Glucocorticoid-remediable hyperaldosteronism (GRE)- Autosomal dominant condition caused by uneven crossing over on chromosome 8. A chimeric protein is created…
An interesting article was published in the August 4th edition of Cell Metabolism. I’m always intrigued when common food ingredients are used to modulate biological systems. This article explores the effect of capsaicin on blood vessel tone. Capsaicin…
Back in the early 1970s researchers traveled into the jungle in Northern Brazil to visit a group of Indians. The Yanamomo tribe had lived in isolation for thousands of years and had only been contacted in the 1950s….
The best answer is D. Lifton et al. described a single gene mutation on the hormone-binding domain of the mineralocorticoid receptor (MCR). Individuals with this missense mutation develop early-onset hypertension with characteristic low renin and aldosterone levels. The…
