Marc Lawrence Soco, MD Internal Medicine Resident Chong Hua Hospital, Cebu City, Philippines @msocoMD Hepatorenal syndrome (HRS) was classically recognized as an all-encompassing term referring to the concurrent failure of the kidneys and the liver. Over the years,…
In the pre-DAA era, the dogma was to treat HCV pre-transplant for two reasons: active HCV increases post-transplant hepatic complications, NODAT, and decreases patient and graft survival and that IFN cannot be used post-transplant because of higher risk…
The Burden of Hepatitis C The estimated global Hepatitis C viral infection (HCV) burden was slashed down to 71 million by the WHO in 2015, from the earlier estimate of 130-150 million, after Rao et all showed that…
In patients with combined renal and liver dysfunction it is important to differentiate between renal impairment that is secondary to liver disease i.e. hepatorenal syndrome, and conditions where an insult directly affects both the liver and kidney. …
Bleeding is a common complication of liver disease and given that we as nephrologists are sometimes asked to place lines or perform renal biopsies on patients with cirrhosis, it is important to know the physiology behind the reason…
In the recent edition of Hepatology, the International Club of Ascites (ICA) have published their revised recommendations on the diagnosis and management of AKI in patients with cirrhosis. They first proposed diagnostic criteria for Hepatorenal syndrome (HRS) in…
You have probably noticed the flurry of articles published this week in the NEJM, coinciding with the International Liver Congress meeting in London, reporting incredible results with new direct-acting antiviral agents in Hepatitis C. This is undoubtedly one…
In my attempt to highlight nephrology content in non-renal journals, I will this month focus on a series of articles in Hepatology concerning eGFR in cirrhotic patients. We are all aware of the concerns using creatinine-based tools for…
Currently there is huge variation in the number patients receiving a kidney transplant at the time of their liver transplant across the US; Combined Liver Kidney Transplant (CLK). The rate of good quality (standard criteria) kidneys being transplanted…
How does sodium retention occur in liver cirrhosis? Most of us accept Schrier’s peripheral arterial vasodilation hypothesis. This hypothesis postulates that overproduction of vasodilatory substances in the splanchnic circulation in cirrhosis leads to splanchnic pooling and decreased “effective”…
