In my experience the appetite to biopsy patients with clinical renal disease varies widely between clinician, institution and country. This is most apparent when it comes to the diabetic patient with renal disease. In my opinion there is…
I recently managed an elderly African American man who was admitted from the clinic for a renal biopsy. He was referred for proteinuria that had not been quantified by his PCP but had been present for over a…
In June’s edition of JASN Jacques et al. highlighted the emerging importance of the role of chloride in the pathogenesis of hypertension. Their group developed a mouse model that over expressed the protein pendrin in the aldosterone-sensitive region…
Currently there is huge variation in the number patients receiving a kidney transplant at the time of their liver transplant across the US; Combined Liver Kidney Transplant (CLK). The rate of good quality (standard criteria) kidneys being transplanted…
Currently there is no good treatment for the most common inherited cause of ESRD, adult polycystic kidney disease. There have been a number of high profile trials in ADPKD in recent years. These trials have endeavored to show…
Nail changes in renal failure: Half and half nails (Lindsay’s nails) can be found in patients with any degree of azotemia. The prevalence is about 21% in dialysis patients. the proximal half of the nail is white and…
Acquired Perforating Dermatoses: Perforating dermatoses are a group of conditions characterized by transepidermal elimination of dermal material (collagen, elastic tissue or necrotic connective tissue) (CMAJ). APD is one of the 4 major perforating disorders: Reactive perforating collagenosis (inherited…
Nephrogenic Systemic Fibrosis (NSF) No post or summary on skin disorders in renal failure can omit NSF. This has been mentioned in multiple previous posts on RFN – although never summarized: The first cases of this disorder were…
Phototoxic skin disorders in renal failure: Patients with renal failure or ESRD secondary SLE can have a photosensitive skin rash. For example: Discoid Lupus Erythematosus (DLE); these lesions are thick and scaly, plug the hair follicles, appear usually…
Nephrology grand rounds in Duke University Medical Center this week inspired me to write this blog on a subject I now realise that I am weak on. Patients on dialysis are a unique group in whom we see…
