Lonely Glomeruli
One of the difficulties in doing molecular research on the kidney is the diversity highly specialized cells that exist in the glomerulus. As a result, it is important to be able to isolate glomerular tissue from the surrounding…
Treatment of IgA Nephropathy – Update
Following on from yesterday’s update on membranous nephropathy, I thought that this would be a good time to give an update on the treatment of another, very common glomerular disease: IgA nephropathy. IgA has been covered extensively on…
Update on Membranous Nephropathy
U Penn established an annual one-day seminar in nephrology symposium. This year was titled “New Horizons in Nephrology: Updates in Glomerular Disease”. Dr. Beck from Boston University gave the update on membranous nephropathy (MN). Previously, we discussed his…
suPARBaby?
The American Journal of Kidney Diseases published a fascinating letter this month from Jochen Reiser’s group concerning the transmission of the suPAR from a mother to her newborn infant. The patient in question had a history of primary…
International Update on Glomerular Disease
On April 27th 2013, a course on glomerular disease will take place at the North Shore University Hospital in Manhasset, New York. This course is being organized by Dr Kenar Jhaveri who is well known to the blogging…
A Gel Coating Your Hairy Endothelium
To follow up on one of Nate’s posts from 2010, hair grows not only on your skin. He describes a glomerular capillary to be hairy. Glycocalyx, a hairy structure attached to the glomerular endothelium, is a mixture of…
Conference Review: Renal Biopsy in Medical Diseases of the Kidneys
I’m not a huge conference goer. I’ve been to ASN a few times and have made a brief appearance at the Advanced Nephrology for the Consultant down in San Diego but otherwise haven’t seen much of the…
Isolated C3 deposits on an inflammed glomeruli
Six months after a kidney transplant, a patient developed a rising creatinine, significant proteinuria (~2g/day), hematuria and low C3 levels. A kidney graft biopsy showed severe glomerulonephritis with mostly occluded capillary loops with immunofluorescence staining negative for immunoglobulins…
Heavy Chain Deposition Disease
As an intern, and I’m sure many can relate to this story, I remember trailing after the team, disheveled and exhausted as we rounded endlessly postcall one day. Our hospital had the county jail contract and as we…
MPGN: Think Different
In the week that Steve Jobs stepped down as CEO of Apple, it seems appropriate to tip our cap to that guru of simplicity, and take a stripped down, simplified approach to one of the biggest quagmires in…