The first kidney transplant between two identical twins, the Merrick brothers, took place on Dec 23, 1956 in Boston, MA and its is very interesting to read the original article and how Dr. Merril and Dr. Murray concluded…
I evaluated a young kidney donor candidate in clinic a few days ago and although he did not have any obvious medical issues and was an excellent candidate, he has been smoking half-a-pack a day of cigarettes for…
Hemolytic uremic syndrome is a thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic hemolytic anemia and renal impairment. Most cases (90%) are secondary to infections, such as E. Coli (serotypes O157:H7, O103:H2). For a more comprehensive review about aHUS, check…
Washington University at St Louis will be holding the inaugural Midwest Transplant Symposium on October 16th and 17th 2015. This course is designed to be an in-depth review and update in kidney and pancreas transplant. 8.5 AMA PRA…
Monoclonal gammopathies generally arise from the development of an abnormal clone of B-cell lineage. The monoclonal protein can be intact immunoglogulin (often associated with free light chain), free light chain (FLC) in isolation, or more rarely immunoglobulin heavy…
Textbooks and formal lectures were previously considered the main sources to build a solid medical knowledge. However, the advancements of technology have transformed our learning process. Nowadays, students, residents and fellows learn from a combination of resources including…
A biopharmaceutical, or biologic, is any medicinal product manufactured in or extracted from a living system, such as a microorganism or plant or animal cells. Several biologic agents are produced using recombinant DNA technology, while others may be…
All HLA antigens are composed of strings of several polymorphic sites, which may serve as targets, or epitopes, for antibody binding. An important consideration is that HLA antigens have multiple epitopes that can be recognized by specific antibodies….
Tacrolimus comes in oral, intravenous and topical formulations. Prograf is the most commonly used oral tacrolimus formulation and is dosed twice daily. Prograf pharmacokinetics Absorption: Absorption occurs in the small intestine. Drug levels reach a maximum concentration in…
In this months edition of JCI a group led by Dr B Murphy from Icahn School of Medicine at Mount Sinai describe a beautiful set of experiments that explain the mechanism by which the CKD and eGFR risk…
