Despite tremendous advancements in transplant and immunosuppressive therapy, transplantation in sensitized patients remains a major challenge. The presence of pre-transplant donor-specific antibodies (DSA) is strongly associated with poor outcomes, hyperacute, and antibody-mediated rejection. Sensitization can occur through blood…
All HLA antigens are composed of strings of several polymorphic sites, which may serve as targets, or epitopes, for antibody binding. An important consideration is that HLA antigens have multiple epitopes that can be recognized by specific antibodies….
I would like to direct your attention to a landmark paper in transplantation just published on the NEJM two weeks ago. We have previously discussed the terms used to characterize sensitized patients and the most common protocols to…
Let’s continue our discussion from our last blog about sensitized kidney recipients. In summary, we have this 60 yo man interested on a second transplant. He has a high PRA (98%) as well as anti-HLA Abs against his…
Another day of transplant clinic… I heard from my attending that a couple is here for a second opinion about a kidney transplant. The husband is a 60 yo male with ESRD 2/2 PKD who had a previous…
