Acute interstitial nephritis (AIN) has resurfaced as an important cause of kidney injury in the hospitalized patient, particularly because of recent evidence implicating such common medications as proton pump inhibitors. Though most current cases of AIN have been…
Although I don’t believe that many will agree that this was the most important paper of the year in the world of nephrology, I do want to give a shout out to a paper published in JCI in…
I recently managed an elderly African American man who was admitted from the clinic for a renal biopsy. He was referred for proteinuria that had not been quantified by his PCP but had been present for over a…
I recently saw an interesting case series published in CJASN where they reported four cases of oliguric AKI associated with synthetic cannabinoids use. Renal biopsy revealed acute tubular injury in three of them and calcium oxalate crystals in…
Cystinosis is an autosomal recessive disease caused by a mutation in CTNS, which encodes the lysosomal transporter of cystine. This leads to intracellular cystine accumulation which leads to renal, neurological and cardiac damage. The treatment for this condition…
Cystinosis is an autosomal recessive disease caused by a mutation in CTNS, which encodes the lysosomal transporter of cystine. Without this, cystine gradually accumulates in cells causing progressive damage. The commonest kind is “nephropathic cystinosis” which is the…
ANATOMYThe tubulointerstial tissue is composed of cortex and medulla. The cortex has type 1 cells resembling fibroblasts and produces Epo. Type 2 cells in the cortex resemble dendritic cells capable of Ag presentation. Furthermore the cortex contains types…
