Preventing Chronic Rejection: Can it B?

For the past 5 years, alloantibody measurement has become a standard of practice in recipients of kidney transplants experiencing worsening allograft function. This week, I admitted a patient who had a rising creatinine and on biopsy mild-moderate interstitial…

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Physiology of serum free light chains

Monoclonal gammopathies generally arise from an abnormal clone that has developed from a single cell of B-cell lineage. The monoclonal protein can be intact immunoglogulin (often associated with free light chain), free light chain (FLC) in isolation, or…

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Lithium-induced nephrotoxicity

I recently saw a patient in my outpatient clinic who was referred for management of chronic kidney disease presumed to be caused by chronic lithium-induced nephrotoxicity. The patient presented with a serum creatinine ranging from 1.4-1.5 mg/dL over…

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