Lithium-induced nephrotoxicity

I recently saw a patient in my outpatient clinic who was referred for management of chronic kidney disease presumed to be caused by chronic lithium-induced nephrotoxicity. The patient presented with a serum creatinine ranging from 1.4-1.5 mg/dL over…

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Confusing Sign

Everyone has a certain diagnosis in Nephrology that is just hard to understand. For me, it has been the diagnosis of MPGN (membranoproliferative glomerulonephritis). After extensive reading, I have developed a couple of pearls and interesting points that…

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Depression in ESRD

This blog post focuses on some of the lesser-discussed aspects of ESRD: depression and psychosocial issues related to ESRD. Studying depression in the ESRD population is an important issue because it is likely the most prevalent psychiatric disease…

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Technology wins again???

The interest in machine perfusion for preservation of kidney transplants has been revived. Were we serious when we decided to put the organ in ice??? A recent NEJM prospective, controlled trial randomizing 336 consecutive deceased donors to either…

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INF2, actin polymerization and FSGS

Focal segmental glomerulosclerosis (FSGS) is a clinicopathologic syndrome manifesting with proteinuria, usually of nephrotic range. Early in the disease process, there is a pattern of glomerular sclerosis that is focal, involving a subset of glomeruli, and segmental, involving…

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