Post by: Dearbhla Kelly, Dublin, Ireland Every so often in the Nephrology clinic, I come across this uncommon, but increasingly recognized entity of IgG4-related disease (IgG4-RD). IgG4-RD is an immune-mediated, fibrous and chronic inflammatory condition that comprises a…
Post by: Namrata Parikh. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune disorders whose hallmark is inflammation of small blood vessels throughout the body, producing a myriad of manifestations. AAV had once been considered to…
Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystem involvement and no cure. Among patients with SLE, roughly 50% develop lupus nephritis and are at risk of developing lupus nephritis-related end-stage kidney disease (ESKD). Current therapies for…
Rituximab, the monoclonal chimeric anti-CD20 antibody, is an effective B-Cell depleting agent and continues to gather data for its use in a wide range of conditions relevant for the Nephrologist. It was also a pre-season favourite in the…
This is a really exciting bracket and is full of new agents that will hopefully lead to major advances in our field. Acthar is the outlier here as, even though it is a peptide, it is not an…
In a year which gave us the bardoxolone failure, NEPHRON-D and the CORAL trial to name a few, a study with a positive result should be celebrated and the RAVE follow-up must be a contender for top 10…
Acute humoral or antibody-mediated rejection (AMR) is attributed to the presence of alloantibodies against the graft, which could be either antibodies against human leukocyte antigens (HLAs) Class I and/or II , non-HLA antigens or endothelial antigens. Diagnosis of…
A 53-year-old Caucasian male presented with pulmonary embolism, and was found to have nephrotic syndrome. A kidney biopsy showed membranous nephropathy (MN). The disease progressed despite treatment and six years later, the patient underwent a pre-emptive living unrelated…
For those of us managing patients with active lupus nephritis, the promise of a safe new therapy five years ago – anti-CD20 monoclonal antibody therapy against B cells- seemed like a breath of fresh air. A number of…
Mixed cryoglobulinemia (MC) is a systemic vasculitis in which B cell clones produce IgM with rheumatoid factor activity. The disease can range in severity from isolated skin lesions to full blown renal and neurological involvement. Most patients are…
