Anti-Nephrin Antibodies in Minimal Change Disease
Approach to the Patient with Peritoneal Dialysis Catheter Dysfunction- Part 1
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Conferences, Courses, & Grants
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Interventional Nephrology Series
Focus on Point-of-Care Ultrasound in Nephrology (POCUN) Series
Kidney Biopsy of the Month Series
Sodium and seizures?
The development of acute hyponatraemia can have profound neurological consequences. After creation of an osmotic gradient between the intravascular compartment and the intracellular compartment, water must somehow gain access to the brain tissue. This appears to be mediated,…
From The RFN Archives: “Full House” Immunostaining
Renal pathologists may throw out the term “full house” immunostaining…what does this mean? This means quite simply that all five major immunofluorescent stains on a renal biopsy (IgM, IgG, IgA, C3, and C1q) are all positive. The analogy…
Facing challenges: Hepatitis C and Kidney Transplantation
Hepatitis C virus (HCV) infection affects more than 180 million people globally, may lead to renal disease and is prevalent in 11-49% of patients with end-stage renal disease, depending on geographical location. With that picture in mind, we…
Don’t forget the vitamins
In the absence of glucose, the brain requires a water-soluble, fat-derived fuel for metabolism and ketoacids serve this function. Unsurprisingly, as a result of this, the main factor controlling the production of ketoacids is the relative lack of…
New to the Blogosphere: The Kidney Doctor
If your looking for something new and interesting in the online Nephrology world check out Dr Ajay Singh’s The Kidney Doctor. Since starting up last month there has already been some great content including a post from the…
Subclavian subterfuge and “Catheter Last”
While performing an electronic chart biopsy prior to examining a consult patient, I noticed a “nephrologic no-no,” which can be seen on the patient’s chest x-ray coursing under the right clavicle (see image). This finding was confirmed on…
Fractional Excretion
The fractional excretion of sodium (FeNa) is a test that is often used in the setting of acute renal failure to help distinguish between pre-renal and intra-renal causes that has been mentioned in previous blog posts. In general,…
From the RFN Archives: Drug-Induced ANCA
A subset of patients with ANCA-associated vasculitis have drug-induced ANCA disease. There are a few features of drug-induced ANCA disease which set it apart from “idiopathic” ANCA disease, but overall the clinical symptoms are similar. Drug-induced ANCA almost always involves…
Moving and grooving: should we bring the gym into the dialysis unit?
Back in 1999, UCSF researchers strapped some high tech motion detectors onto about 30 patients on dialysis and compared one week’s worth of activity to that of matched controls. Mind you, these control patients were selected to be…
AKI and Fluid Overload
Even in my limited experience as a first year fellow, it seems that the decision to institute RRT seems to hinge on an idiosyncratic blend of patient and center-specific parameters. I was not surprised to learn that there…