We have all been taught that before making the diagnosis of SIADH, we have to ensure that the patient has normal adrenal and thyroid axes. Why is this so important and how do thyroid and adrenal dysfunction cause…
I’ve recently had the privilege of caring for a patient undergoing chemotherapy for a metastatic malignancy using agents targeting the vascular endothelial growth factor (VEGF) pathway. This patient, having tolerated three cycles of avastin and ipilumimab without any…
The renin-angiotensin system is powerful regulator of blood pressure homeostasis. An article published in the March 24 issue of JASN highlights an emerging area of research into the modulation of AT1 receptors on different tissues. The majority of…
It seems like there have been a lot of recent developments in the management of hypertension, and several sacred cows have become burgermeat. I thought I’d summarize a few of these important developments here: 1. Blood pressure targets…
Happy World Kidney Day! Celebrated every year in March, World Kidney Day is a day devoted to raising awareness of kidney disease across the globe. This year promised to be a huge success: cities throughout the world, from…
I have just learned two very interesting aspects of kidney donation that I would like to share with you. As part of my transplant fellowship, I am required to participate in the decisions about accepting or not a…
This is one that Nate would have liked….I recently saw a case of renal disease in an albino Peurto Rican woman with severe pulmonary fibrosis. She holds the diagnosis of Hermansky-Pudlak Syndrome (HPS).HPS is an autosomal recessive disorder…
Talking to Nate always stimulated new ideas and new challenges. Last time I met him, we played soccer in the park with the kids (that was also a challenge but fun and easy to win…). We also talked…
The kidney contributes to glucose homeostasis by reabsorbing ~180 grams of glucose daily. Two sodium-coupled glucose transporters play an important role in this process, SGLT1 and SGLT2. Of these two, SGLT2 (encoded by the gene SLC5A2 on chromosome…
I am currently a clinical fellow, slogging through another consult month. As I am sure many of you have experienced, consult questions often come in batches. At least three times this week we have been called to see…