VEGF inhibitors and proteinuria

I’ve recently had the privilege of caring for a patient undergoing chemotherapy for a metastatic malignancy using agents targeting the vascular endothelial growth factor (VEGF) pathway. This patient, having tolerated three cycles of avastin and ipilumimab without any…

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A trap for angiotensin type 1 receptors

The renin-angiotensin system is powerful regulator of blood pressure homeostasis. An article published in the March 24 issue of JASN highlights an emerging area of research into the modulation of AT1 receptors on different tissues. The majority of…

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Mythbusters: Hypertension

It seems like there have been a lot of recent developments in the management of hypertension, and several sacred cows have become burgermeat. I thought I’d summarize a few of these important developments here: 1. Blood pressure targets…

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World Kidney Day 2010

Happy World Kidney Day! Celebrated every year in March, World Kidney Day is a day devoted to raising awareness of kidney disease across the globe. This year promised to be a huge success: cities throughout the world, from…

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Lack of respect for the beans

I have just learned two very interesting aspects of kidney donation that I would like to share with you. As part of my transplant fellowship, I am required to participate in the decisions about accepting or not a…

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Hermansky-Pudlak Syndrome

This is one that Nate would have liked….I recently saw a case of renal disease in an albino Peurto Rican woman with severe pulmonary fibrosis. She holds the diagnosis of Hermansky-Pudlak Syndrome (HPS).HPS is an autosomal recessive disorder…

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Alimentary Azotemia?

I am currently a clinical fellow, slogging through another consult month. As I am sure many of you have experienced, consult questions often come in batches. At least three times this week we have been called to see…

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