Ischemia-Reperfusion Models

The study of AKI/ATN has relied heavily on one particular animal model: the warm ischemia-reflow model (often referred to as “ischemia-reperfusion injury”), in which one of the renal arteries is transiently ligated off for a set period of…

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Transplant Glomerulopathy

As acute rejection rates continue to fall, causes of late allograft loss, such as transplant glomerulopathy (TG), become increasingly important. TG should spring to mind when you encounter a renal transplant recipient who develops heavy proteinuria and progressive…

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Atypical HUS & Orphan Drugs

Atypical HUS refers to hemolytic uremic syndrome which occurs without E. coli 0157:H7-induced diarrhea as the inciting event. There are many causes of atypical HUS: calcineurin inhibitors, HIV, pneumococcal infection and rare genetic diseases are all on the…

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Hemoperfusion

The first order of business for today’s Renal Fellow Network is to welcome another regular contributor to the mix: nephrology fellow Albert Lam, of Brigham & Women’s Hospital. Fresh off the Nephrology boards, Albert will be periodically posting…

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Low Vitamin D Levels Predict ESRD

Hypovitaminosis D is implicated in a wide variety of disease states, including insulin resistance and diabetes, cancer and cardiovascular disease. A new new study in JASN suggests it may also influence the development of de-novo renal disease. The…

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Nephrotoxic HIV Drugs

I’ve done a post on renal-relevant HIV drugs previously, but I just heard an interesting case of tenofovir-induced renal failure at our Renal Grand Rounds and thought I’d mention a few interesting tidbits from the presentation. 1. HIV-Associated…

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