The study of AKI/ATN has relied heavily on one particular animal model: the warm ischemia-reflow model (often referred to as “ischemia-reperfusion injury”), in which one of the renal arteries is transiently ligated off for a set period of…
The results of last week’s poll on IgA Nephropathy are in: 90% of individuals correctly identified that the only treatment shown in randomized controlled trials to consistently benefit patients with IgA Nephropathy is ACE-inhibitors and/or ARBs. The response…
As acute rejection rates continue to fall, causes of late allograft loss, such as transplant glomerulopathy (TG), become increasingly important. TG should spring to mind when you encounter a renal transplant recipient who develops heavy proteinuria and progressive…
Atypical HUS refers to hemolytic uremic syndrome which occurs without E. coli 0157:H7-induced diarrhea as the inciting event. There are many causes of atypical HUS: calcineurin inhibitors, HIV, pneumococcal infection and rare genetic diseases are all on the…
The first order of business for today’s Renal Fellow Network is to welcome another regular contributor to the mix: nephrology fellow Albert Lam, of Brigham & Women’s Hospital. Fresh off the Nephrology boards, Albert will be periodically posting…
While there are a number of conditions which can cause the combination of hypokalemia and metabolic alkalosis there are a limited number of disease processes which lead to hypokalemia, metabolic alkalosis, AND hypertension. In order to have hypertension…
A very interesting article in this month’s JASN by Herlitz et al describes a cohort of 10 bodybuilders with chronic kidney disease, making a compelling case that anabolic steroid use is an underrecognized cause of secondary FSGS. The…
Poll results from last week’s question regarding anemia management in the dialysis patient. Interestingly, there was a fairly strong consensus on this one, with over 75% of individuals electing to give a course of iv iron to the…
Hypovitaminosis D is implicated in a wide variety of disease states, including insulin resistance and diabetes, cancer and cardiovascular disease. A new new study in JASN suggests it may also influence the development of de-novo renal disease. The…
I’ve done a post on renal-relevant HIV drugs previously, but I just heard an interesting case of tenofovir-induced renal failure at our Renal Grand Rounds and thought I’d mention a few interesting tidbits from the presentation. 1. HIV-Associated…