There is a good review article in this month’s NEJM entitled “Use of Diuretics in Patients with Hypertension” by Ernst and Moser which focuses predominantly on the thiazide class of diuretics. The thiazides are considered a FUNCTIONAL rather…
One of the things I was definitely grateful for at this year’s Thanksgiving table: I’m not on-call and can spend the holiday with my family! Best wishes to those renal fellows working hard on this holiday. Poll Results…
In my experience, it’s unusual to perform a transplant nephrectomy in a patient who has returned to dialysis in the absence of a ‘hard’ indication such as macroscopic hematuria or severe symptoms suggestive of rejection or infarction. There…
One of the hallmarks of autosomal dominant polycystic kidney disease (ADPKD) is hypertension. True, most patients with advanced kidney disease get hypertension anyways–but often the degree of hypertension in ADPKD patients seems to be especially high. Is there…
Very cool project: The Nephrology Oral History Project. On their homepage you can access interviews with 14 different nephrologists who practiced during the early days of dialysis, as early as the 1950s and 1960s. It’s well-organized in that…
It’s the weekend, I need to decompress from the boards. Here’s some random kidney-related clips. The first is pretty bizarre. This next one is pretty basic, but the animation is good.
I saw an interesting case yesterday. A 71 year old male, CKD III with a syndrome suggestive of chronic tubulointerstitial disease (U/A trace proteinuria only, disproportionate anemia, mild cortical thinning on ultrasound, normal-appearing vasculature on ultrasound). He had…
First things first: last week’s poll results showed that the majority of individuals were wary of using physician “Pay For Performance” as a strategy towards increasing AV fistula placement rates. Proponents of this strategy (see editorial by Hakim…
Another day, another negative study… this is getting painful! The large, randomized ASTRAL trial comparing renal revascularization to medical therapy found no benefit, and substantial increased risk, in the interventional arm. 806 patients with atherosclerotic reno-vascular disease were…
Antibodies are comprised of the structure noted on the left: they have two immunoglobulin heavy chains (in blue) and two immunoglobulin light chains (in green), covalently linked with one another via disulfide bonds (in red). The light chains…