atheroembolic renal disease

I heard a lecture not too long ago on atheroembolic renal disease which claimed that atheroembolic renal disease is to nephrology as sarcoidosis is to internal medicine. That is to say, it can present in a myriad of…

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Reticular Inclusions in HIVAN

The histology of HIVAN (HIV-Associated Nephropathy), at the light microscopy level, is indistinguishable from that of collapsing FSGS: the glomerular capillary loops are collapsed. Furthermore, both entities demonstrate foot process effacement (as in all forms of nephrotic syndrome)…

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MMF Basics

Mycophenolic acid is a commonly encountered medication in nephrology. In addition to its use in the vast majority of kidney transplant recipients as part of the immunosuppressive regimen, it is also gaining popularity in the treatment of immune-mediated…

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Rituxan for Membranous Nephropathy?

Clinical trials evaluating the efficacy of various therapies of membranous nephropathy is a tricky business, given the natural history of the disease: because about 1/3 of patients spontaneously remit, it is often difficult to say that a patient’s…

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By the Numbers: Dialysis Providers

This is an interesting figure, taken from the 2008 USRDS (United States Renal Disease System) Atlas, which illustrates where patients in the U.S. are getting their dialysis from these days. Nearly 63% of all patients are getting dialysis…

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How much Cytoxan is too much?

Cytoxan is a very potent but also potentially toxic medication used for a variety of immune-mediated (and nephrology-relevant) diseases. It is often classified as a “cytotoxic agent”, as it works as an alkylating agent that explains its utility…

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The Polypill

This week’s Lancet has an interesting article from The Indian Polycap Study (TIPS), in which investigators tested the efficacy and tolerability of a single pill containing up to FIVE different cardiovascular medications:  a beta-blocker, an ACE-inhibitor, a thiazide…

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