hepatitis C & cryoglobulinemia

Prior to the discovery of the hepatitis C virus (viral particles shown on the left), there was an entity termed “essential cryoglobulinemia”–that is, cryoglobulinemia without an obvious explanation.  While this term is still used, the true “essential cryoglobulinemia”…

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ABO Incompatibility Renal Transplant

Although the traditional dogma of kidney transplant would state that ABO incompatibility is an absolute contraindication for a kidney transplant, this is changing:  there are some overall favorable reports of graft longevity in Japan, where cadaveric kidneys are…

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hemojuvelin

Several months back I posted something on hepcidin–the 25 amino acid peptide secreted by the liver which appears to be the “master regulator” of iron metabolism, and whose levels appear to be perhaps increased in ESRD patients, providing…

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Routine Urinalysis Screening?

Is it a good idea to screen the pediatric population at-large for hematuria and proteinuria?   This is  a controversial topic, as generally speaking isolated hematuria or isolated proteinuria are almost always benign findings in pediatric populations, and…

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Xanthogranulomatous pyelonephritis

Xanthogranulomatous pyelonephritis (XGP) is a rare but severe complication of chronic UTIs. I think of it (in simplistic terms) as a pyelonephritis so severe that it results in loss of renal function of the affected kidney as well…

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Sodium Thiosulfate for Calciphylaxis

Calciphylaxis is a rare but severe dermatologic condition affecting end-stage renal disease individuals for reasons which remain obscure. Histologic biopsy is the gold-standard for making the diagnosis; it typically demonstrates calcification within the media of small and medium-sized…

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2003 Lupus Nephritis Classification Updates

The World Health Organization (WHO) of lupus nephritis has provided a useful and simple framework for understanding this complex disease. In 2003, a committe of the International Society of Nephrology (ISN) & Renal Pathologic Society (RPS) instituted some…

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MDRD II

Continuing on with a brief discussion of the landmark MDRD Study: at the time of the study, several smaller studies suggested that a low protein diet would prolong time to ESRD for patients with CKD. The theory was…

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