Bardoxolone – Part 3

Last year, we had a post about Bardoxolone for the treatment of diabetic nephropathy. After one year of treatment, eGFR increased significantly in patients treated with Bardoxolone relative to controls. At the time, significant concerns were raised about…

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One flew over

When I got my US driving license, I was asked whether or not I would like to be an organ donor. To me, having seen the positive effects of donation on the lives of my patients down through…

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A Quest for a Pot of Gold

In the quest for better solute clearance, two divergent paths were taken on each side of the Atlantic. The US nephrology community has concentrated more on low weight molecules. The European counterpart has focused on both low and…

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From acid to nephrocalcinosis to stones

Can you have an acidosis with normal serum bicarbonate? Of course you can, it’s just incomplete. Incomplete distal renal tubular acidosis (idRTA) that is. RTA was first described in 1935, confirmed as a renal tubular disorder in 1946,…

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Hawaii and Population Management

How familiar are the following scenarios to you? You’re in clinic and have just seen a 69 year old man with a longstanding history of hypertension.  He has been referred by his internist to nephrology for an eGFR…

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