CKD Guidelines

AJKD this month has an extended editorial section on the KDOQI guidelines for CKD. It is now 10 years since these guidelines were introduced and their impact on nephrology has been significant, not least due to the fact…

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Less is More

Despite the fact that the kidney ultrasound is generally obtained as one of multiple recommendations when evaluating AKI, the benefit of kidney ultrasound is not clear. The post-renal causes of AKI are not very common. It adds to…

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To biopsy or not to biopsy – IgA

The topic of IgA nephropathy has been discussed in multiple posts here in the past. IgA is the commonest primary GN with a wide variety of presentations and prognoses ranging from isolated hematuria to a rapidly progressive GN….

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Rapamycin and PCKD

A couple of years ago, it was noted that mTOR inhibitors slowed the growth of cysts in animal models of Polycystic Kidney Disease. Although the activity of mTOR is minimal in normal renal epithelial cells, in cyst epithelial…

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Bardoxolone – Part 3

Last year, we had a post about Bardoxolone for the treatment of diabetic nephropathy. After one year of treatment, eGFR increased significantly in patients treated with Bardoxolone relative to controls. At the time, significant concerns were raised about…

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One flew over

When I got my US driving license, I was asked whether or not I would like to be an organ donor. To me, having seen the positive effects of donation on the lives of my patients down through…

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