Laura Slattery, Specialist Registrar in Nephrology and General Internal Medicine, Royal College of Physicians, Dublin. Paracetamol or acetaminophen ingestion can result in a variety of toxic syndromes predominantly related to alterations of glutathione metabolism and/or depletion of glutathione…
Metabolic acidosis is a common condition encountered routinely by Nephrologists. Etiology of this condition is quite varied often requiring detailed history and a battery of tests to tease out the diagnosis. In most of the scenarios, co-existing biochemical…
Welcome to the first case of the Skeleton Key Group, a team of twenty odd nephrology fellows who work together to build a monthly education package for Renal Fellow Network. The cases are actual cases that intrigued the…
Benjamin Abelow’s book: The Painless Guide to Mastering Clinical Acid-Base is available again as a free download in recognition of the new class of incoming nephrology fellows. We have highlighted this book in the past. It is a…
The MUDPALES mnemonic for raised anion gap acidosis was drilled into me from medical school. However recently after working through each category I became stumped when nothing ticked the box to identify the cause. The lady I had…
I recently presented the case of a middle-aged man with a history of a remote Roux-en-Y gastric bypass, chronic diarrhea, and colon cancer on chemotherapy who initially presented with progressive fatigue and weakness in the setting of increased…
Apologies to Ben for the delay in posting about this. Ben Abelow is an MD in New Haven who has long had an interest in teaching basic acid base physiology. In the late 1990s he published a primer…
The electrolyte bracket contains a mixture of the old staples of nephrology mixed with some new kids on the block trying to muscle in on established territory, Vaptans vs hypertonic saline and ZS-9 vs Kayexalate. Hypertonic saline is…
Fluid therapy is essential in ICUs and not surprisingly there is still much controversy about which fluid to use, how much and when. Nephrologists often roll their eyes at other subspecialty’s preferences, e.g. surgeon’s preferences for Ringers, citing…
Can you have an acidosis with normal serum bicarbonate? Of course you can, it’s just incomplete. Incomplete distal renal tubular acidosis (idRTA) that is. RTA was first described in 1935, confirmed as a renal tubular disorder in 1946,…
