Our focus on myeloma related disorders continues- view previous posts here. Pathogenesis C3GN is a type of glomerulonephritis characterized by dominant C3 deposition resulting from overactivation of the alternative pathway of complement (APC) from acquired or hereditary causes. The…
Our focus on myeloma related disorders continues- view previous posts here. Pathogenesis Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGNMID) is seen in less than 1% of native kidneys and is due to IgG kappa (IgG3 most commonly) deposition in…
Our focus on myeloma related disorders continues- view previous posts here. Glomerular diseases with organized deposits belong to a broad group of paraprotein-related diseases that affect the kidneys. The presence of substructure or organization to deposits is often…
We continue a focus on features of myeloma kidney. Previous posts available here. Monoclonal immunoglobulin deposition diseases (MIDD) are systemic disorders characterized by deposition of monoclonal immunoglobulins involving all components of the renal parenchyma including glomerular and tubular…
We continue the focus on Myeloma kidney, which started last month with Light Chain Cast Nephropathy. This month the emphasis is on Light Chain Proximal Tubulopathy with Crystals (LCPT)- a distinct entity. Terminology Chronic tubulointerstitial nephropathy caused by…
Introduction Light chain cast nephropathy (LCCN), not to be confused with light chain deposition disease (LCDD), is also known as myeloma cast nephropathy or myeloma kidney; and is one of the many renal complications of multiple myeloma. Patients…
