In the week that Steve Jobs stepped down as CEO of Apple, it seems appropriate to tip our cap to that guru of simplicity, and take a stripped down, simplified approach to one of the biggest quagmires in…
Hypertonicity in kidney medullary interstitium is essential for urinary concentration. Osmolality in the papillary interstitium can reach up to 1200 mOsm/kg. How do cells in the renal medullary interstitium survive this hypertonic stress? Virtually all cells respond to…
Also in this months issue of AJKD is a very well written piece by Dr Peter Laird of HemoDoc and Dialysis from the sharp end of the needle in the In a Few Words section on his own…
Shameless plug. Check out the just released AJKD article, Embracing the Internet as a Means of Enhancing Medical Education in Nephrology by Matt and Conall along with Kenar and Sidharth from Nephron Power.
As nephrology fellows we see a lot of Acute Kidney Injury (AKI) on the inpatient consultative service. When AKI in the hospital requires dialysis people and their families naturally want to know whether this means long term dialysis…
Cholera epidemics have been a major public health issue throughout recorded history and much energy was devoted towards preventing them and treating affected patients once they occurred. However, it was not until 1831 that it was recognized that…
I would like to direct your attention to a landmark paper in transplantation just published on the NEJM two weeks ago. We have previously discussed the terms used to characterize sensitized patients and the most common protocols to…
Here are some simple facts about urine specific gravity, osmolality and their determination from the urinalysis. Specific gravity The reference substance for comparative purposes is water, which therefore has a specific gravity of 1.000. The so-called normal ranges…
My name is Will Pendergraft, and I just completed the clinical portion of the joint nephrology fellowship between Brigham and Women’s Hospital and Massachusetts General Hospital. I was inspired for the first time by Nate Hellman during my…
Gearoid did a nice job reviewing the recent exciting findings surrounding primary Focal Segment Glomerulosclerosis (FSGS) and I thought it would be a good opportunity to review some of the sometimes confusing terminology and clinical basics. To start,…