Tamm-Horsfall Protein and Kidney Disease

Tamm-Horsfall protein (THP), or uromodulin, is a glycoprotein secreted by the renal epithelium, best known as the proteinacious framework of all urinary casts. It’s function in health is an enigma, but prevention of bacterial colonization of the urinary…

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Warfarin and Vascular Calcification

Warfarin has recently been associated with an increased risk of stroke in ESRD patients with atrial fibrillation. This makes the decision whether to initiate warfarin therapy in dialysis patients with atrial fibrilltion anything but clear cut. Add to…

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Drug Trials

Last week’s poll results:  who should provide funding for large, randomized controlled drug trials?  Most respondents (58%) chose the diplomatic answer and said that it should be a combination between government and pharmaceutical companies.  I was somewhat surprised…

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The trials of a lab rat…

I was on the phone to one of my friends the other day. He’s a renal fellow currently doing lab-based research in Boston. He’s been having a difficult time of it lately, with none of his experiments working…

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