Rapamycin for ADPKD?

Another potentially useful drug to prevent cyst growth in autosomal dominant polycystic kidney disease comes from the interesting observation that kidney transplant patients with native ADPKD kidneys who were given an immunosuppressant regimen containing the drug rapamycin (sirolimus)…

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PRES

The MRI above depicts a classic example of posterior reversible encephalopathy syndrome (PRES), sometimes also called reversible posterior leukoencephalopathy, an increasingly-recognized consequence of malignant hypertension.  The whitish areas (“hyper-intense signal”) in the bilateral occipital and parietal lobes represent…

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A recession-proof profession?

How many nephrologists does the U.S. need? I recently heard a thought-provoking calculation from MGH’s Dr. David Steele which helps illustrate a likely shortage in the number of American nephrologists.  The calculation is admittedly a rough estimate, but…

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Why Do U.S. ESRD Patients Do So Poorly?

The Dialysis Outcomes and Practice Patterns Study (DOPPS) is an important longitudinal study of ESRD patients in multiple countries, and is the source of much respected epidemiologic data on dialysis patients worldwide. Interestingly, the DOPPS estimated the crude…

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Nephrology Pearls Courtesy of Hippocrates

A cool article from this month’s AJKD describes several of the Nephrology-related aphorisms originally penned by Hippocrates sometime around 400 BCE. These brief, pithy sayings probably represent the earliest attempts to understand the kidney in health and disease…

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Utility of Testing For Eosinophiluria

Testing for the presence of urine eosinophils is often performed when the diagnosis of acute interstitial nephritis is suspected.  The landmark paper touting the use of this test is a 1986 New England Journal of Medicine article by…

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The Acanthocyte

We’re all taught that looking for dysmorphic red blood cells on urinalysis is a useful marker of glomerular hematuria.  But how do we define “dysmorphic”?  And how was this association originally studied?  One landmark paper was this 1991…

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