Genome-Wide Association Study for CKD

A recent article just published in Nature Genetics by Kottgen et al identifies several loci which appear to confer susceptibility to the development of CKD.  How did researchers identify these genes?  By a genome-wide association study.  Briefly, researchers…

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Kidney-Themed 30 Rock Episode

The NBC show “30 Rock” featured a humorous, kidney-themed season finale last Thursday. If you don’t feel like watching the full 30-minute episode, you can purchase the full music video for the song “We Need A Kidney” at…

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GBM Collagens & Alport’s Syndrome

Alport’s Syndrome is a genetic disorder characterized by glomerulonephritis, progression to ESRD, and hearing loss. Intriguingly, it can be inherited in either an X-linked, autosomal recessive, or autosomal dominant manner. Why is the inheritance pattern so complex and…

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Big Pharma Nephrology

The following is a list of major pharmaceutical companies, ranked by total revenue. The numbers are staggeringly high. #1 overall is Johnson & Johnson ($ 63,747,000,000 in 2008 total revenue), followed by Pfizer and Bayer. A few of…

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Stranded on a Lifeboat

We all know that if you are stranded on a lifeboat in the middle of the ocean, you are not supposed to drink the salt water.  Why is this the case–shouldn’t the kidney be smart enough to retain…

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Transvaginal Nephrectomy

Recently two separate groups have reported the successful carrying out of the first-ever human transvaginal nephrectomy–one report coming from the Cleveland Clinic and another from Venezuela. The surgery is being developed as an even less invasive surgical approach…

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Chronic Pain in ADPKD

About 60% of all ADPKD patients are estimated to have a chronic pain syndrome, and often this is the initially presenting symptom of an ADPKD patient that brings them to medical attention. An excellent review of this field…

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Two-Hit Hypothesis & ADPKD

One of the really interesting aspects of autosomal dominant polycystic kidney disease (ADPKD) is that only about 1% of all nephrons form cysts. You can do the math: if you have about 1 million nephrons per kidney, and…

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