Acquired Perforating Dermatoses: Perforating dermatoses are a group of conditions characterized by transepidermal elimination of dermal material (collagen, elastic tissue or necrotic connective tissue) (CMAJ). APD is one of the 4 major perforating disorders: Reactive perforating collagenosis (inherited…
Nephrogenic Systemic Fibrosis (NSF) No post or summary on skin disorders in renal failure can omit NSF. This has been mentioned in multiple previous posts on RFN – although never summarized: The first cases of this disorder were…
Though adult nephrologists infrequently encounter these disorders in clinic, the Board Exam loves them. Below a short table describing some of these gain- and loss-of-function channel disorders that are worth remembering. The diuretic-targeted channels are shown under parenthesis…
One of the issues surrounding the study of bardoxolone in animal models was that, because of the way that it is metabolized in rats and mice, it is highly toxic when given for long periods. This specific toxicity…
JAMA has a new platform called the JAMA Network Reader that you can use to get access to content from any of the JAMA journals (includes what were formerly called Archives of …). All the content (which includes…
Phototoxic skin disorders in renal failure: Patients with renal failure or ESRD secondary SLE can have a photosensitive skin rash. For example: Discoid Lupus Erythematosus (DLE); these lesions are thick and scaly, plug the hair follicles, appear usually…
With the results of the eAJKD brackets posted by Gearoid, I thought this article might be pertinent to stimulate further the debate… This article just came out on Transplantation and is a well designed study in which the…
These are my brackets for the eAJKD nephmadness. My winner is a number 10 seed coming out of left field. For me, the importance of the MDRD trial is that it highlighted the high prevalence of CKD in…
Nephrology grand rounds in Duke University Medical Center this week inspired me to write this blog on a subject I now realise that I am weak on. Patients on dialysis are a unique group in whom we see…