A man in his 30s with no significant medical history presented to the ED following a fainting episode. Routine screening found an abnormal creatinine, hematuria and proteinuria. Serological work-up including complements were negative. In view of a slowly…
In 2007, the Food and Drug Administration (FDA) was granted the authority to require pharmaceutical manufacturers to develop risk evaluation and mitigation strategies (REMS), if deemed necessary. This was made possible by the FDA Amendment Act, which also…
1) Topiramate – Watch for non-gap acidosis, nephrolithiasis and hyperammonemia. 2) Jak2 – the intracellular kinase activated by the binding of Epo to the Epo receptor. 3) Live vaccines are contraindicated in kidney transplant recipients – these include MMR, Varicella, Yellow…
Please join us on Friday for the Annual Bloggers Night! Time:FridayNovember 2nd, 20128:30pmPlace:Barleymash 600 5th Ave (between G St & Market St)San Diego, CA 92101
In celebration of our 1000th post, we asked Matt Sparks. a former editor of the Renal Fellow Network who is now a faculty member at Duke University in North Carolina for his perspective on his time with this…
I was recently rounding on a gentleman in the ICU with acute promyelocytic leukemia (APL) who, after starting induction therapy with tretinoin (all-trans retinoic acid), developed fever, hypotension, new pulmonary infiltrates with associated respiratory failure and AKI requiring…
1) Isopropyl alcohol does NOT cause an elevated anion gap acidosis, retinal toxicity (as does methanol), or renal failure (as does ethylene glycol). 2) Fibril diameter of the more common fibrillary diseases – Amyloid, Fibrillary GN, and Immunotactoid GP – is correlated…
So after many months and a few intensive weeks of study the nephrology boards are now in the record books and I thought I’d examine what worked and didn’t work in my study efforts. If you’re part of…
This month’s eJournal Club concerns a paper (with an accompanying editorial) reporting the experience of renal biopsies in Norway. One issue that arises again and again is whether or not patients should undergo outpatient biopsies. The argument against…
Sometimes when something appears too good to be true, it is too good to be true. Last year, a paper was published in the NEJM reporting a preliminary study of bardoxolone for the treatment of diabetic nephropathy. At…