Monoclonal gammopathies generally arise from the development of an abnormal clone of B-cell lineage. The monoclonal protein can be intact immunoglogulin (often associated with free light chain), free light chain (FLC) in isolation, or more rarely immunoglobulin heavy…
The use of evidence-based diagnosis is what we are taught that we should all do but in practice, this is quite difficult. EBM diagnoses rely on likelihood ratios but it is impossible to remember the diagnostic accuracy of…
With the proliferation of new therapies for cancer including novel targeted therapies, it is difficult to keep up with the potential renal problems related to these medications. Thankfully, Nature Reviews Nephrology have published a comprehensive review of the…
One of the regular criticisms of nephrology is the lack of good quality randomized controlled trials. This is particularly the case in the world of renal bone disease where we target surrogate endpoints without necessarily knowing for certain…
Chronic kidney disease (CKD) patients develop significant changes in bone mineral density (BMD) and bone structure, which together with an increased risk for falls, put them at high risk for fracture. This can be due, in part, to…
Prevention of perioperative AKI, mostly from ATN by ischemic insult, has been a major challenge in nephrology. Recent study (Zarbock et al. JAMA) showed a simple, non-invasive method—remote ischemic preconditioning (RIPC), could be a promising strategy. This multicenter,…
The American Society of Nephrology (ASN), in collaboration with a research team from George Washington University (GWU), is conducting its 2nd annual survey of fellows training in nephrology. The goal of this important survey is to better understand…
Textbooks and formal lectures were previously considered the main sources to build a solid medical knowledge. However, the advancements of technology have transformed our learning process. Nowadays, students, residents and fellows learn from a combination of resources including…
I recently admitted a woman overnight with prerenal AKI and serum K+ of 7 mmol/L. A passing ED physician mumbled to me not to worry as their ECG didn’t require calcium gluconate, and besides, they had an ICD inserted recently….
A biopharmaceutical, or biologic, is any medicinal product manufactured in or extracted from a living system, such as a microorganism or plant or animal cells. Several biologic agents are produced using recombinant DNA technology, while others may be…