Anti-Nephrin Antibodies in Minimal Change Disease
Approach to the Patient with Peritoneal Dialysis Catheter Dysfunction- Part 1
Want to write a case report? RFN has you covered with a list of journals to choose from
Have a Nephrology Question? There Might Be A #Tweetorial For That!
Conferences, Courses, & Grants
FOAMed
Interventional Nephrology Series
Focus on Point-of-Care Ultrasound in Nephrology (POCUN) Series
Kidney Biopsy of the Month Series
Board question: Water-1 answer
This was an actual case I saw and thought it generated a multitude of interesting dilemmas. When I initially examined the patient she was in status epilepticus. This, by itself, mandated the immediate correction of her serum sodium….
This isn’t meant to be happening…
A paradigm of modern genetic studies, such as GWAS, is that there is a natural balance to allelic variation, with common variation in the population conferring mild disease risk and, conversely, genes of strong disease effect being rare….
Board question of the week: Water-1
A 40-year-old woman is rushed to ER for change in mental status. She has a history of multiple sclerosis and alcohol abuse. On arrival to ER, she exhibits 3 stereotyped, tonic-clonic seizure that resolve with ativan. The initial…
Shaken not stirred…
Not long ago while on call I received a midnight consult for hyperkalemia. The patient had a history notable for CLL, who was electively admitted to for induction chemotherapy. Prior to this admission, he had received no previous…
Femoral versus Jugular, part two
I have always been told that the jugular veins are preferable over the femoral veins when inserting temporary dialysis catheters. Various reasons are put forward for this including increased risk of infection and poor function of femoral catheters…
Hot peppers for hypertension?
An interesting article was published in the August 4th edition of Cell Metabolism. I’m always intrigued when common food ingredients are used to modulate biological systems. This article explores the effect of capsaicin on blood vessel tone. Capsaicin…
Doc, I am very sensitized!
Another day of transplant clinic… I heard from my attending that a couple is here for a second opinion about a kidney transplant. The husband is a 60 yo male with ESRD 2/2 PKD who had a previous…
Tubulointerstitial disease
ANATOMYThe tubulointerstial tissue is composed of cortex and medulla. The cortex has type 1 cells resembling fibroblasts and produces Epo. Type 2 cells in the cortex resemble dendritic cells capable of Ag presentation. Furthermore the cortex contains types…
Should we give up on anti-B-cell antibody therapy in the treatment of lupus nephritis?
For those of us managing patients with active lupus nephritis, the promise of a safe new therapy five years ago – anti-CD20 monoclonal antibody therapy against B cells- seemed like a breath of fresh air. A number of…
Mmm, let’s try rituximab
Mixed cryoglobulinemia (MC) is a systemic vasculitis in which B cell clones produce IgM with rheumatoid factor activity. The disease can range in severity from isolated skin lesions to full blown renal and neurological involvement. Most patients are…