ASN’s New Logo

The American Society revealed its new logo with the new year: a male form with two glowing kidneys visible inside him, striding into the future (at least, that’s my interpretation as to what he is doing–I guess alternate…

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Interferon effects on the kidney

Interferons are cytokines which play a central role in the inflammatory response, and commercially prepared interferons have proven useful in the treatment of several diseases. For instance, interferon-alpha (often used in conjunction with ribavirin) is often used in…

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Gadolinium Beliefs

Poll results from last week:  The majority of individuals (60%) felt that it was definitely unsafe giving gadolinium to ESRD patients, with 45% of individuals also agreeing that it was unsafe in CKD stage 4.  As is consistent…

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Bortezomib in Myeloma Cast Nephropathy

Bortezomib is a proteosome inhibitor used primarily in the treatment of relapsed myeloma. However, it is increasingly being used in the management of myeloma cast nephropathy (MCN). Bortezomib binds to, and inhibits the function of, the 26S proteosome…

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Polycystic Kidney Disease, mTOR and Sirolimus

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the gradual enlargement of multiple fluid filled cysts in both kidneys, which compress and destroy normal adjacent nephrons, typically resulting in ESRD by the fifth decade of life. Management…

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