Useful Autoantibodies in Lupus Nephritis

Quick review of the autoantibodies that may be useful in the diagnosis and management of patients with lupus-related kidney disease: anti-nuclear antibody (ANA):  as well as know from our internal medicine days:  very sensitive, but not very specific….

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Use of Hypoglycemic Agents in CKD

Maintaining adequate glycemic control in patients with diabetic kidney disease can be a challenge.  First, it is hypothesized that worsened glycemic control will lead to a greater tendency towards diabetic nephropathy.  Second, individuals with more advanced CKD are…

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Renal Transplant “Matchmaker” Busted

As has been extensively detailed over the past week, one of the key guilty parties in the large federal sting operation exposing shockingly Sopranos-type corruption throughout the state of New Jersey was this man: Levy Isaac Rosenbaum, allegedly…

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EAST Syndrome

A relatively recent study by Bockenhauer et al in NEJM reports the identification of a new disease gene in a rare tubulopathy syndrome that sheds light on the physiologic mechanisms of salt transport in the kidney. The article…

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cyclosporine versus tacrolimus

The two calcineurin inhibitors routinely used for kidney transplant immunosuppression are cyclosporine (CSA) and tacrolimus (TAC).  Their mechanism of action is somewhat similar (they both inhibit calcineurin, which under normal circumstances induces transcription of IL-2 in lymphocytes) but…

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Surgery Intern Boy Band

Okay, I’ll admit, there’s no Nephrology tie-in here. But props to the Mass General Hospital surgical interns for using their undoubtedly sparse spare time to make this ridiculous music video.

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Kidney transplant lingo

Continuing with the theme of yesterday’s Kidney Transplant post, here are some commonly-used Kidney Transplant Lingo & Acronyms: CRT/DDKT: CRT = cadaveric renal transplant, which is starting to be replaced by DDKT (deceased donor kidney transplant)–I guess some…

We Need More Kidneys!

Example of a paper whose conclusion is summed up quite nicely in the full title:  “Half of Kidney Transplant Candidates Who Are Older than 60 Years Now Placed on the Waiting List Will Die before Receiving a Deceased-Donor…

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