Anti-Nephrin Antibodies in Minimal Change Disease
Approach to the Patient with Peritoneal Dialysis Catheter Dysfunction- Part 1
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Renal Failure in the Neuro ICU
Here are a few important guidelines for prescribing RRT in the Neuro ICU gleaned from this review. First off, a recap of the physiology… Intracranial pressure increases are buffered by CSF, such that increased ICP leads to increased…
How to best design RCTs for new transplant immunosuppressives
The ability to adequately suppress the immune system and prevent allograft rejection has been a true success story over the past several decades. With the advent of drugs such as calcineurin inhibitors, induction agents such as thymoglobulin, azathioprine…
Differential diagnosis of hypouricemia
Hypouricemia is defined as a serum uric acid level less than 2mg/dL. Although it is generally considered benign, hypouricemia has been associated with several important conditions relevant to nephrologists, including acute kidney injury, uric acid nephrolithiasis, and SIADH…
Gordon Syndrome
File “Gordon Syndrome” under “interesting causes of hyperkalemia and metabolic acidosis you may never see.” Also called pseudohypoaldosteronism type II, Gordon Syndrome is relevant less so for the number of patients afflicted but more due to the interesting…
Drugs Associated with Hyperkalemia
There are a variety of drugs which can result in hyperkalemia, via a variety of mechanisms. Here are a list of some of the common offenders, categorized loosely based on mechanism, though admittedly there is some overlap between…
Is renal replacement in nursing home residents futile?
Geriatric nephrology is in focus in this weeks NEJM with this excellent article by Tamura et al. By linking the USRDS database to a national registry of nursing home residents, they were able to document changes in functional…
An Ever-So Slight Victory for PD?
It was a close vote that came down to the wire, but there was an ever-so slight preference for peritoneal dialysis modalities (53% CAPD+CCPD) as compared to hemodialysis modalities (47% standard hemo + home hemo) when RFN readers…
Revised diagnostic criteria of HRS
They may have struggled to get girlfriends in college, but members of the International Ascites Club do call the shots when it comes to defining hepato-renal syndrome (HRS). As they were published in Gut, their revised criteria for…
The Electrolyte Composition of the Dead Sea
The Dead Sea, located between Israel and Jordan, is considered one the saltiest bodies of water on earth, giving swimmers a peculiar buoyancy when immersed. Interestingly, the electrolyte composition of the Dead Sea is quite different from that…
Acid-Base Issues Related to Eating Disorders
There are some interesting acid-base perturbations that can take place in the setting of eating disorders and/or surreptitious use of substances used to intentionally lose weight. Due to the surreptitious nature of many of these disorders, some lab…