In 1971, a group of virologists in London first described a novel polyomavirus they discovered in the urine and urothelial cells of a kidney transplant recipient who had developed ureteric stenosis. Named after the patient it was first…
Thrombotic microangiopathy (TMA) is characterized by microvascular endothelial injury and thrombosis, presenting both clinically and histopathologically in two main forms; acute and chronic TMA. Etiology and Clinical Presentation Table 1: Etiologies of TMA classified according to clinical presentation…
Amyloidoses are a group of diseases resulting from deposition of amyloid, insoluble fibrils derived from various precursor proteins, into extracellular tissues. Amyloidoses are acquired or hereditary, and depending on where amyloid deposits, can affect a wide range of…
Our last post on lupus nephritis focused on pathogenesis ,clinical presentation, grading and class I/II disease. The next segment this month will cover class III-VI disease. Class III: Focal lupus nephritis It accounts for about 9-24% of lupus…
Our endeavor for the next 2 months will be a focus on Lupus nephritis. This month we will cover general aspects of disease, introduction to subclasses and activity indexes. Background and Demographics Systemic lupus erythematosus (SLE) is a…
Introduction Atheroembolic kidney disease develops due to occlusion of small renal arteries by cholesterol crystal emboli originating from the rupture of atheromatous aortic plaques. It is part of a systemic disease and embolization often affects other organs such…
Our focus on myeloma related disorders continues- view previous posts here. Pathogenesis C3GN is a type of glomerulonephritis characterized by dominant C3 deposition resulting from overactivation of the alternative pathway of complement (APC) from acquired or hereditary causes. The…
Our focus on myeloma related disorders continues- view previous posts here. Pathogenesis Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGNMID) is seen in less than 1% of native kidneys and is due to IgG kappa (IgG3 most commonly) deposition in…
We continue a focus on features of myeloma kidney. Previous posts available here. Monoclonal immunoglobulin deposition diseases (MIDD) are systemic disorders characterized by deposition of monoclonal immunoglobulins involving all components of the renal parenchyma including glomerular and tubular…
Introduction Light chain cast nephropathy (LCCN), not to be confused with light chain deposition disease (LCDD), is also known as myeloma cast nephropathy or myeloma kidney; and is one of the many renal complications of multiple myeloma. Patients…
