In 2012, the introduction of the “monoclonal gammopathy of renal significance” (MGRS) for kidney disease associated with monoclonal proteins was revolutionary. MGRS was now clearly different from the benign monoclonal gammopathy of undetermined significance (MGUS). Prior to the…
Red Blood Cell (RBC) Casts:RBC casts (Fig. 1) are an important finding in the urinary sediment and most often signify the presence of a proliferative glomerulonephritis or vasculitic process. Although less common, RBC casts may also be seen…
Introduction Physical examination is a quick and inexpensive way of diagnosing stenosis and other causes of vascular access dysfunction. Its ability to reliably detect stenotic lesions compared with ultrasound and angiography (the gold standard), has repeatedly been demonstrated….
Fibrillary glomerulonephritis (GN) is a rare disease which accounts for about 1% of all kidney biopsies. The very first description of the disease was published by Rosenmann and Eliakim in 1977. They described a patient with nephrotic syndrome…
The tubulointerstitium of the kidney is broadly divided into the cortex and the medulla. These are extremely important components of the kidney, which can show a broad spectrum of changes ranging from subtle to significant, in both acute…
I grew up in León city, Nicaragua. León is known locally as the home of the oldest university in Nicaragua and it is located very close to the Pacific Ocean. The lack of a formal education makes it…
One of my mentors, Dr. Fred Silva, frequently reminds us that “the kidney has a limited number of ways to respond to an innumerable number of injuries”. For this reason, studying kidney pathology is challenging and fun. Since…
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease, affecting 1/400 to 1/1000 live births and is the fourth leading cause of end-stage kidney disease in adults. Both types of ADPKD (1 and 2) typically have…
The UK Renal Association SpR Club and Kidney Research UK are delighted to invite you to their Spring meeting for 2019 – ‘Updates in Nephrology’. This will be held on March 16-17th in the beautiful city of Edinburgh….
Anorexia nervosa is characterized by caloric restriction and pathologic behaviors to achieve weight loss, such as excessive exercising, dieting, or purging (e.g. abuse of laxatives or diuretics, surreptitious vomiting). Patients with bulimia nervosa engage in purging behaviors and…